Question 1

What is creatinine clearance?

Accepted Answer

Creatinine clearance (CrCl) is a measure of kidney function that estimates the glomerular filtration rate (GFR). It reflects how efficiently the kidneys filter creatinine from the blood and is measured in mL/min.

Question 2

What is the Cockcroft-Gault formula?

Accepted Answer

CrCl = [(140 - Age) × Weight (kg)] / [72 × Serum Creatinine (mg/dL)] × 0.85 if female. It was published by Cockcroft and Gault in 1976 and remains the standard for drug dosing adjustments.

Question 3

What creatinine clearance is considered normal?

Accepted Answer

Normal creatinine clearance is approximately 90-120 mL/min for healthy adults. Values below 60 mL/min indicate chronic kidney disease (CKD) Stage 3 or worse. Below 15 mL/min indicates kidney failure (Stage 5).

Creatinine Clearance (Cockcroft-Gault)

Clinical Application

Mathematical Metric

Evidence & Lit

Suggested Diagnostic Protocols